Curriculum vita
(updated 6/1/10)

Michael Blaber, Ph.D.
Department of Biomedical Sciences
College of Medicine
Florida State University
Tallahassee, FL 32306-4300
TEL: (850) 644-3361 FAX: (850) 644-5781
michael.blaber@med.fsu.edu

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Education

Ph.D., Biological Chemistry, University of California, Irvine CA Major Professor: Dr. Ralph A. Bradshaw (9/85-2/90)
B.A., Biochemistry/Molecular Biology, University of California, Santa Barbara CA (9/76-6/80)

Professional Experience

Faculty, Program in Neuroscience, Florida State University, Tallahassee FL (4/10-present)
Invited Research Fellow, Quantum Beam Science Directorate, Japan Atomic Energy Agency (JAEA) (09-10)
Professor of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee FL (8/07-present)
Associate Professor of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee FL (8/05-7/07)
Associate Professor of Chemistry, College of Arts & Sciences, Florida State University, Tallahassee FL (8/00-7/05)
Faculty, Program in Molecular Biophysics, Florida State University, Tallahassee FL (8/94-present)
Assistant Professor of Chemistry, College of Arts & Sciences, Florida State University, Tallahassee FL (8/94-7/00)
Postdoctoral Fellow, Institute of Molecular Biology, University of Oregon, Eugene OR Postdoctoral Advisor: Dr. Brian W. Matthews (3/90-7/94)
Research Associate, Department of Protein Chemistry, Genentech, Inc., South San Francisco, CA (9/80-8/85)

Awards

U.S. Patent 7,754,216 B2, Method of Treating Multiple Sclerosis with Anti-K6 Antibody, Scarisbrick, I.A., Blaber, S.I., Blaber, M. and Rodriguez, M. (7/10)
U.S. Patent 11/001,804, Engineered Human Acidic Fibroblast Growth Factors and Associated Methods, Blaber, M. and Brych, S. (6/10)
U.S. Patent 7,696,171, Mutant Polypeptides of Fibroblast Growth Factor 1, Blaber, M. and Dubey, V.K. (4/10)
U.S. Patent 7,659,379, Mutants of Human Fibroblast Growth Factor Having Increased Stability and/or Mitogenic Potency, Blaber, M. and Dubey, V.K. (2/10) 
U.S. Patent 7,595,296, Mutant Polypeptides of Fibroblast Growth Factor 1, Blaber, M. and Dubey, V.K. (9/09)
E.K. Frey-E. Werle Commemorative Gold Medal (09)
Faculty Ranking #1, Department of Biomedical Sciences, Florida State University (09)
European Patent 1,513,553 B1, Methods and Materials for Treating and Diagnosing Kallikrein-6 Related Inflammatory Conditions, Scarisbrick, I.A., Blaber, S.I. and Blaber, M. (11/08)
Outstanding Senior Faculty Researcher Award, Department of Biomedical Sciences, College of Medicine, Florida State University (07)
FSU Innovator Award, Florida State University (04, 06, 07)
U.S. Patent 0,127,391 A1, Methods and Materials for Treating Inflammatory Conditions, Scarisbrick, I.A., Blaber, S.I., Blaber, M. and Moses, R. (5/03; pending)
Faculty Ranking #1, Department of Chemistry & Biochemistry, Florida State University (02)
U.S. Patent 0,146,731 A1, Synthetic Nucleic Acid Sequences for 2,5-Diketo-D-Gluconic Acid Reductases and Associated Methods, Sanli, G., Blaber, S.I. and Blaber, M. (1/02; pending)
Tenured, Florida State University (9/00)
University Teaching Award, Florida State University, Tallahassee FL (4/99)
First Year Assistant Professor Award, FSU, Tallahassee FL (5/95)
N.I.H. Postdoctoral Fellowship GM13709-01, Institute of Molecular Biology, University of Oregon, Eugene OR (3/90-2/93)
N.I.H. Predoctoral Fellowship GM07134-11, University of California, Irvine CA (9/86-8/89)
Earl C. Anthony Dissertation Fellowship, University of California, Irvine CA (9/89-12/89)
U.S. Patent 5,219,569, Protease Resistant Urokinase, Blaber, M., Heyneker, H.L. and Vehar, G.A. (6/93)

 

Teaching - Courses Developed

BCH4053L Biochemistry Lab (Undergraduate, HTML format. http://mikeblaber.org/oldwine/BCH4053l/bch4053l.htm) FSU (1/04)
BCH4053 Biochemistry I (Undergraduate, HTML format. http://mikeblaber.org/oldwine/BCH4053/bch4053.htm) FSU (9/01)
CHM 1046 General Chemistry II (Undergraduate, HTML format. http://mikeblaber.org/oldwine/chm1046/chm1046.htm) FSU (1/00)
CHM 1045 General Chemistry I (Undergraduate, HTML format, http://mikeblaber.org/oldwine/chm1045/chm1045.htm) FSU (4/99)
BCH 5425 Molecular Biology and Biotechnology (Graduate, HTML format, http://mikeblaber.org/oldwine/bch5425/bch5425.htm) FSU (1/96)
BCH 5887 Protein Structure and Stability FSU (9/95)

Teaching - Courses Taught

BMS 6401 Medical Pharmacology (small group facilitation) FSU (Sp 09, Sp 10)
BMS 6301 General Medical Microbiology (small group facilitation) FSU (F 09)
BMS 5525: Bioregulation (2 lectures on Molec. Visualization, Protein/Nucleic Acid Interactions) FSU (Sp 08, Sp 09, Sp 10)
BMS 6204 Medical Biochemistry (28 lectures) FSU (Sp 07)
BMS 6110C Clinical Microanatomy (small group facilitation) FSU (F 05, F 06)
BMS 6204 Medical Biochemistry (small group facilitation) FSU (Sp 06, Sp 07)
BMS 6520 Systemic Physiology (small group facilitation) FSU (Sp 06-Sp 09)
BMS 6001 Epigenetics (team lectures) FSU (Sp 06)
BMS 6601 General Pathology & Immunology (small group facilitation) FSU (F 05-F 09, Sp 10)
BCH 4053L Biochemistry Lab (Undergraduate) FSU (Sp 04)
BMS 6204 Medical Biochemistry, Protein Structure and Folding FSU (Sp 02, Sp 03)
BCH 4053 Biochemistry I (Undergraduate) FSU (F 01-F 03)
CHM 1046 General Chemistry II (Undergraduate) FSU (Sp 00-Sp 03)
CHM 1045 General Chemistry I (Undergraduate distance learning) FSU (Su 99)
BCH 5425 Molecular Biology and Biotechnology (Graduate) FSU (Sp 96-Sp 99)
CHM 1045 General Chemistry I (Undergraduate) FSU (F 96, F 98-F 00)
BCH 5887 Protein Structure and Stability (Graduate) FSU (F 95)

Postdoctoral Fellows Trained

Dr. Hyesook Yoon (2009-) Ph.D. 2008 Department of Chemistry & Biochemistry, Florida State University, Tallahassee FL
Dr. Jihun Lee (2007-) Ph.D. 2007 Department of Chemistry & Biochemistry, Florida State University, Tallahassee FL
Dr. Akshaya Kumar Meher (2007-2008) Ph.D. 2007 Central Drug Research Institute, Lucknow India
Dr. Vikash Kumar Dubey (2004-2006) Ph.D. 2003 Banaras Hindu University. Current position: Assistant Professor, India Institute of Technology, Guwahati India
Dr. Jhimli Dasgupta (2004-2005) Ph.D. 2004 Saha Institute of Nuclear Physics
Dr. Steven Whitten (1999-2000, Co-P.I. with Dr. Timothy Logan). Ph.D. 1999 Johns Hopkins University. Current position: Research Scientist, Red Storm Scientific, LLC, 2200 Market Street, Suite 703, Galveston TX
Dr. Sumit Khurana (1997-1999). Ph.D. 1996 India Institute of Technology. Current position: Sr. Research Scientist, Immunomics Operations, Beckman Coulter Inc., 7330 Carroll Road, San Diego CA
Dr. Ramesh Badisa (1998). Ph.D. 1996 All India Institute of Medical Sciences. Current position: Research Scientist, Walker Cancer Research Institute, 1634 Metropolitan Boulevard, Tallahassee FL

Graduate Students - Major Professor

Sara Jackson, Biomedical Sciences, FSU (10-present)
Liam Longo, Molecular Biophysics, FSU (10-present)
Cristina Russo, Ph.D., Molecular Biophysics, (Co-advisor with Dr. Marcia Fenley) FSU (05-10), Salt-dependence of protein-DNA binding: insights into protein electrostatics and redesign
Hyesook Yoon, Ph.D., Chemistry and Biochemistry, FSU (05-08), Activation profiles and regulatory cascades of the Human Kallikrein-related peptidases
Nikki Held, M.S. Chemistry and Biochemistry, FSU (05-06)
Jihun Lee, Ph.D. Chemistry and Biochemistry, FSU (03-07), Characterization of the Effects of b-Turn Sequence on Protein Stability, Folding Kinetics, Functionality and Turn Structure, Current position: Postdoctoral Researcher, Department of Biomedical Sciences, Florida State University, FL
Gurunathan Laxmikanthan, Ph.D. Chemistry and Biochemistry, FSU (02-06), AHA Predoctoral Fellowship, An Insight into the Structure, Function and Activation Cascades of the Classical Human Kallikreins Current position: Postdoctoral Researcher, Brown University, Providence, RI
Jocelyn Dudley, M.S. Chemistry and Biochemistry, FSU (02-05), NSF GK-12 Fellowship
Matthew Bernett, Ph.D. Chemistry, FSU (01-04), High-Resolution Structures of the Proteins Human Kallikrein 6 and Human Fibroblast Growth Factor-1: Structure and Function Relationships. Current position: Research Scientist, Xencor Inc., Monrovia CA
Stephen Brych, Ph.D. Chemistry, FSU (99-04), NSF Fellowship, A Redesigned Hydrophobic Core of a Symmetric Protein Superfold with Increased Primary Structure Symmetry. Current position: Research Scientist, Pharmaceutics, Amgen, Thousand Oaks CA
Jae-won Kim, Ph.D. Chemistry, FSU (99-03), Structure and Biophysical Characterization of b-turn of Human Acidic Fibroblast Growth Factor. Current position: Research Scientist, Amgen, Seattle WA
Gulsah Sanli, Ph.D. Chemistry, FSU (98-02), Expression and Structural Characterization of 2,5-Diketo-D-Gluconic Acid Reductase : A Commercially Important Enzyme for Biosynthesis of Vitamin C. Current position: Assistant Professor, Department of Chemistry, Izmir Institute of Technology, Turkey
Heidi Wenger, M.S., Chemistry, FSU (98-99,02)
Frank J. Culajay, M.S. Biology, FSU (96-00), Thermodynamic Characterization of Mutations of Human Acidic Fibroblast Growth Factor. Current position:Sr. Research Scientist, MD Anderson Cancer Center, Houston TX
Daniel Adamek, Ph.D. Molecular Biophysics, FSU (95-02) Co-P.I. with Dr. D.L.D. Caspar, Characterization of the Hydrophobic Cavity of Interleukin 1-Beta, Current position: Research Scientist, Marshall Space Flight Center, NASA
Elodie Lang, M.S., Chemistry, FSU (94-96), Current position: Marketing Manager, Laboratoires Prodene Klint, Paris France
Aleksandar Popovic, M.S., Chemistry, FSU (94-96), Current position: Minister of Science and Environmental Protection, Government of Serbia

Graduate Students - Graduate Committee

Ian Walton, Chemistry & Biochemistry, FSU (10-present)
Anna Lomasney, Chemistry & Biochemistry, FSU (09-present)
Van Quach, Chemistry & Biochemistry, FSU (09)
Robert Demont, Chemistry & Biochemistry, FSU (09-present)
Robert Harris, Molecular Biophysics, FSU (09-present)
Xu Wang, Chemistry & Biochemistry, FSU (08-present)
Casey O'Brien, Chemistry & Biochemistry, FSU (08-present)
Larry Walker, Chemistry & Biochemistry, FSU (08-present)
Bodhand Dhole, Biology, FSU (07-present)
Deepa Salagala, Molecular Biophysics, FSU (07-present)
Qiyu Zhu, Chemistry & Biochemistry, FSU (07-present)
Richard Chi, Biology, FSU (06-present)
Jyotica Batra, Physics, FSU (06-present)
Alex Chew, Molecular Biophysics, FSU (06-09)
Lee Miller, Chemistry & Biochemistry, FSU (06-07)
Boris Breiner, Chemistry & Biochemistry, FSU (06-07)
Karen Alvarez-Delfin, Biology, FSU (05-present)
Pallavi Tawdi, Biology, FSU (05-08)
Shenping Wu, Molecular Biophysics, FSU (05-08)
Heather Ongley, Chemistry and Biochemistry, FSU (05-07)
Ramzi Alsallaq, Molecular Biophysics, FSU (05-07)
Zhang, Xiaojun, Biology, FSU (04-08)
Mioara Larion, Chemistry and Biochemistry, FSU (04-06)
Sumiko Takahashi, Chemistry and Biochemistry, FSU (04-06)
Sri Oruganti, Chemistry and Biochemistry, FSU (03-07)
Maria Semavina, Molecular Biophysics, FSU (03-06)
Ilker Sen, Molecular Biophysics, FSU (03-07)
Sunjin Jo, Chemistry and Biochemistry, FSU (03-07)
Geoffrey C. Klein, Chemistry and Biochemistry, FSU (03-05)
Yun Kang, Biology, FSU (02-07)
Weishu Bu, Molecular Biophysics, FSU (01-07)
Mohammad Yousef, Molecular Biophysics, FSU (00-03)
Laura Mertz, Chemistry, FSU (99-00)
Anne Stone, Molecular Biophysics, FSU (98-99)
Pamela Twigg, Molecular Biophysics, FSU (98-02)
James Gattis, Chemistry, FSU (98-04)
Maria Elena Vasquez, Mathematics, FSU (98-00)
Jeffery Haber, Molecular Biophysics, FSU (98-99)
Alla Korpanova, Molecular Biophysics, FSU (97-01)
Ken Mann, M.S., Biology, FSU (96-98)
Li Zhang, M.S., Chemistry, FSU (96-97)
Ana deCarvalho, Biology, FSU (96-01)
Scott Olenych, Biology, FSU (96-present)
Virginia A. Gottschalk, Biology, FSU (96-01)
Eric Fontano, Molecular Biophysics, FSU (96-01)
John H. Evans IV, Biology, FSU (96-97)
Brian Patterson, Chemistry, FSU (96-99)
Paul Schmidt, M.S., Chemistry, FSU (96-97)
Delbert D. Bauzon, M.S., Chemistry, FSU (95-97)
Zivana Tezak, Ph.D., Biology, FSU (94-97)

Undergraduate Students

Michael Binner, Direceted Independent Studies (Sp 10-Su 10)
Elise Gunzburger, Research Assistant (Su 09)
Miles Bradshaw, Honors Thesis Committee (F 07-F 09)
Annalise Smith, Independent Research Experience (co-mentored by Dr. Marcia Fenley) (Su 08-F 08)
Winston Lee, Research Assistant (Su 08-Sp10)
Eric Aspinwall, Independent Research Experience (Sp 08-Sp 09)
Farhan Abdul Rashid, Work study (F 07), Directed Independent Studies (Sp 08-F 08)
Marni Becker, Directed Independent Studies (F 07-Sp 08)
Collin Tully, Volunteer Research Assistant (F 07)
Chris Carr, Directed Independent Studies (Su 06)
Benjamin Katz, Honors Thesis Committee (F 05-F 07)
Sharmeel Maraj, Directed Independent Studies (Sp 06)
Jazmin Overton, Directed Independent Studies (Sp 06)
Liam Longo, Directed Independent Studies (F 05-Sp 09); Recipient of American Cancer Society Fisher Undergraduate Fellowship (Su 08), Florida State University Undergraduate Research and Creative Endeavors (URACE) Award (Su 08)
Mei-Ling Shotts, Directed Independent Studies (Sp 05-Sp 06)
Lauren Seabrooks, Directed Independent Studies (Sp 05); Hughes Fellow (Su 05 - Sp 06)
Laura Griffith, Directed Independent Studies (Sp 05)
Aaron Rodriquez, Directed Independent Studies (F 04-Sp 06)
Shadee Thomas Lake, Directed Independent Studies (F 04)
John Jacob, Hughes Fellow (Su 04-Sp 05)
Michael Miller, Directed Independent Studies, FSU (F 03-Sp 04), Hughes Fellow (Su 04 - Sp 05)
Jamie Woodcock, Directed Independent Studies, FSU (Su 03-Sp 04)
Stephen Viel, Directed Independent Studies, FSU (Su 03-Sp 04)
Joanna Balsamo, Directed Independent Studies, FSU (F 02-Sp 03)
Nicholas Frost, Directed Independent Studies, FSU (F 01-Sp 03) Recipient of American Cancer Society Fisher Undergraduate Fellowship (Su 02)
Scott Agbuya, Directed Independent Studies, FSU (Su 01-Su 02)
Ginger Spielmann, Directed Independent Studies, FSU (Su 01-Su 02)
Jenni Chikar, Independent Research Experience (Su 01-F 02)
Kim Pause, Independent Research Experience (Su 01-F 02)
Stephen Klusza, Honors Thesis Committee, FSU (F 00)
Colleen Mulvey, Honors Thesis Committee, FSU (F 00)
Michele Blanco, Directed Independent Studies, FSU (F 00)
William Paneral, Directed Independent Studies, FSU (Su 00)
Amy Peterson, Honors Thesis Committee, FSU (Sp 00)
Binitie Odian, Honors Thesis Committee, FSU (Sp 00)
Cherra Pumphrey, Directed Independent Studies, FSU (F 99)
John Davis, Directed Independent Studies, FSU (F 99, Sp 00)
Sarah Brockway, Honors Thesis Committee, FSU (Sp 00)
Nathan Noble, Directed Independent Studies, FSU (Sp 99)
David Kennedy, Directed Independent Studies, FSU (F 98-Sp 99)
Kesha Williams, Directed Independent Studies, FSU (Sp 98-Sp 99) Recipient of NSF Undergraduate Research Fellowship (F98)
Jaime Schiller, Directed Independent Studies, FSU (Sp 97)
Emily Earp, Directed Independent Studies, FSU (Sp 97)
Sasha Grek, Directed Independent Studies, FSU (Sp 97-Su 00) Recipient of American Cancer Society Fisher Undergraduate Fellowship (Su 97), Florida Space Grant Consortium Fellowship (Su 98), American Cancer Society Fisher Undergraduate Fellowship (Su 99), Caffrey Fellowship (Sp 99)
Jorge Hernandez, Directed Independent Studies, FSU (F 96)
Stephanie Dillon, Directed Independent Studies, FSU (Su 96)
William Greenleaf, Chemistry 1051L (Honors), FSU (Sp 96)
Cinthia Hahm, Directed Independent Studies, FSU (F 95-Sp 96)
Daniel Adamek, Directed Independent Studies, FSU (Su 95-F 95)
Amanda Childers, Chemistry 1051L (Honors), FSU (Sp 95)
Nicole Alavi, Chemistry 1051L (Honors), FSU (Sp 95)

Service

Editorial and Advisory Boards:
Editorial Board, Research and Reports in Biology (10-present)
Editor, Journal of Proteins and Proteomics (8/08-present)
Scientific Advisory Board, Zign Therapeutics Inc. (08-09)
Scientific Advisory Board, CardioVascular BioTherapeutics Inc. (08)
Editorial Advisory Board, Protein Science (1/03-12/05; 1/06-12/08)
Editorial Board, Molecular and Cellular Proteomics (6/01-8/06)

Peer Review:
N.I.H. Macromolecular Structure and Function (MSFC) Study Section (ad hoc) (2/08)
National Science Foundation, Integrative Organismal Biology Panel Ad hoc (8/05)
National Science Foundation, Molecular Biochemistry Panel (10/04 - 4/08)
American Heart Association, Cell Function & Metabolism (10/04 - 10/06)
National Science Foundation, Molecular Biochemistry Ad hoc. (9/04)
National Science Foundation, Molecular Biophysics Ad hoc. (8/04)
N.I.H. High End Shared Instrumentation ZRG1 BPC-D 30 1 (6/04)
American Heart Association, Southern and Ohio Valley Research Consortium, Committee 3A (3/04)
NASA (NRA 00-HEDS-03 Cellular and Macromolecular Biotechnology), Structural Biology Panel (01)
American Cancer Society, Florida Division (96-03)
Petroleum Research Foundation Ad hoc (96,00,05)

Organizer/Officer:
International Scientific Advisory Board, 3^nd International Kallikrein Meeting (2008)
Scientific Organization Committee, 2^nd International Kallikrein Meeting (2007)
Immediate past Chair (1/04-12/04), Chair, (1/04-12/04), Chair-elect (1/03-12/03), Chair-elect-designate (1/02-12/02) American Chemical Society, Florida Section
James R. Fisher Fellowship Committee, American Cancer Society, Florida Section (2003 - present)
Program Chair, Florida Annual Meeting and Exposition of the American Chemical Society (FAME), (2003)
Co-Chair, Protein Engineering Session, American Chemical Society, Southeast Region (SERMACS) (01)
Chair, Scientific Session, American Cancer Society, Florida Division (97)

Outreach:
Godby High School Science Fair Judge (04,06,08,09)
Chair, Alumni Newsletter Committee, Department of Chemistry, FSU (02-03)
Chiles High School Science Fair Judge (00, 04)
Capital Regional Science Fair Judge, Leon County (98,99,02,05,07,10)
Lincoln High School Science Fair Judge (97)

Departmental/University:
Mission Statement Committee, Department of Biomedical Sciences, FSU (Su 10)
Chair, Translational Science Laboratory Search Committee, College of Medicine, FSU (Sp 10)
Department of Biomedical Sciences Faculty Evaluation Committee (Sp 10)
Web Site Development Committee, College of Medicine, FSU (09-10)
Faculty Development Committee, Department of Biomedical Sciences (F09-present)
Member, Neuroscience Graduate Program Committee, FSU (09-10)
Director, Invited Seminar Speaker Series, College of Medicine (09-10)
Dean Search Committee, College of Medicine (F 07-S 08)
Chair, Bylaws and Policy Committee, Department of Biomedical Sciences (F 06-present)
Core Lab Faculty Users Committee, Department of Biomedical Sciences (F 06)
Faculty Development Committee, Department of Biomedical Sciences (F 06)
Chair, Graduate Recruiting and Admissions Committee, Department of Biomedical Sciences (F 06)
Human Subjects Institutional Review Board, Florida State University (Sp 06)
Graduate Recruiting and Admissions Committee, Department of Biomedical Sciences (F 05-07)
Chemistry Screening Committee, CSIT Faculty Search, FSU (Su 01)
Director, Graduate Recruiting and Admissions Committee, Department of Chemistry, FSU (Su 00-Su 02)
Computational Structural Biology 2001 Symposium Committee, FSU (Sp 00)
Executive Committee, Department of Chemistry, FSU (Sp 00-Su 03)
General Chemistry Committee, Department of Chemistry, FSU (Sp 00-present)
Molecular Recognition Initiative Building Committee, Department of Chemistry, FSU (Sp 00)
Merit Committee, Department of Chemistry, FSU (F 99)
Research Training Grant Computational Committee, FSU (Sp 99)
Structural Biology Scientific Advisory Committee, FSU (Sp 98-present)
Graduate Advising Policy Committee, Department of Chemistry, FSU (Sp 98)
Nominating Committee for Director, Institute of Molecular Biophysics, FSU (F 97)
Building Committee, Institute of Molecular Biophysics, FSU (F 97)
Executive Committee, Institute of Molecular Biophysics, FSU (F 96, Sp01-Su03)
Cell Culture Oversight Committee, Institute of Molecular Biophysics, FSU (F 96-present)
Graduate Student Selection Committee, Molecular Biophysics, FSU (Sp 95-Sp 98, Sp03-present)
Michael Kasha Award Committee, FSU (Sp 95)
Graduate Recruiting and Advising Committee, Department of Chemistry, FSU (F 95-present)
Biochemistry Faculty Search Committee, Department of Chemistry, FSU (F 95)
Bylaws Committee, Department of Chemistry, FSU (F 95)
Biochemistry Faculty Search Committee, Department of Chemistry, FSU (F 94)
Organic Faculty Search Committee, Department of Chemistry, FSU (F 94)

Funding - External

33. NINDS Administrative Supplements for Summer Research Experiences, (1R15NS057771-01), Blaber, M. (P.I.) $18,392 (6/1/09-8/31/10)
32. Enterprise Florida SBIR/STTR Phase 0 Pilot Program, Michael Blaber (P.I.), Development of Second-generation Forms of Fibroblast Growth Factor-1 for Pro-angiogenic Therapy. $3,000 (11/13/08)
31. Dept. of Health and Human Services, Public Health Service (1R01NS052741-01A2), Scarisbrick, I.A. (P.I.), Regulation and Function of Kallikreins in Spinal Cord Injury and Repair. Sub-contract award to Blaber, M. $252,636 ($171,862 direct) (4/1/08-3/31/13)
30. Dept. of Health and Human Services, Public Health Service (1R15NS057771-01), Blaber, M. (P.I.), Interactions between CNS-specific Human Kallikreins and the PA System in Inflammation. $220,500 ($150,000 direct) (1/1/07-12/31/09)
29. American Heart Association (0655133B), Blaber, M. (P.I.), Characterization of Fibroblast Growth Factor-1 Mutants with Enhanced Properties for Angiogenic Therapy. $264,000 ($240,000 direct) (7/06 - 6/09)
28. National Multiple Sclerosis Society - Pilot Award (PP1113), Blaber, M. (P.I.), Identification of Activation Cascades Involving Human Kallikrein 6. $44,000 ($40,000 direct) (3/05 - 2/06)
27. National Science Foundation (MCB 0314740), Blaber, M. (P.I.), Probing the Role of Primary Sequence Asymmetry in a Symmetric Superfold. $391,660 ($280,357 direct) (8/03 - 7/06)
26. Berlex Biosciences, Blaber, M. (P.I.), Production of Recombinant Active Rat Kallikrein 6 Protein. $23,597 ($16,162 direct) (4/03 - 7/03)
25. National Multiple Sclerosis Society (RG 3406-A-2), Blaber, M. (P.I.), Regulation and Structural Study of a Novel Protease Implicated in Demyelination. $342,021 ($313,201 direct) (4/03 - 3/06)
24. National Multiple Sclerosis Society - Pilot Award (PP0757), Blaber, M. (P.I.), Enzymatic Characterization of a Novel CNS-specific Serine Protease. $27,500 ($25,000 direct) (9/00 - 8/01)
23. Future Graph, Inc., Blaber, M. (P.I.), Licensing of Web-based Undergraduate Chemistry Instructional Material. $3,000 (12/99)
22. American Heart Association, Established Investigator Grant (0040235N) Blaber, M. (P.I.),Structure, Stability and Functional Studies of 2,5-Diketo-D-Gluconate Reductases. $299,453 ($272,230 direct) (1/00 - 12/03)
21. Florida Space Grant Consortium, Blaber, M. (P.I.),Deconvolution of Calorimetric Data for Protein Stability Studies. $14,000 (direct) (5/98-4/99)
20. Dept. of Health and Human Services, Public Health Service (GM54429-01), Blaber, M. (P.I.), Structure, Stability and Regulation of Human Acidic FGF. $500,000 ($350,000 direct) (5/96-5/01)
19. American Heart Association, Blaber, M. (P.I.), Design of a Thermostable Human Acidic Fibroblast Growth Factor. $270,000 ($255,000 direct) (4/96-5/99) (Note: declined due to overlapping N.I.H. grant award)
18. MicroCal, Inc. Travel Award, Blaber, M., 1st International Conference on the Applications of Biocalorimetry. $500 (6/96)
17. Finn Wold Travel Award, Blaber, M., Protein Society Meeting. $400 (4/96)
16. American Cancer Society, Florida Division - Starter Grant (F95FU-1), Blaber, M. (P.I.), The Role of Protein Stability in the Regulation of Human Acidic Fibroblast Growth Factor. $22,000 (direct) (6/95-5/96)

Funding - Internal

15. Florida State University, Council on Research and Creativity Planning Grant, Blaber, M. (P.I.), Combinatorial Protein Redesign for Enhanced Thermostability. $24,000 (11/07)
14. Florida State University Research Foundation, IRB Research & Creative Activity Award, Blaber, M. (P.I.), $5,000 (7/1/07-6/30/08)
13. Florida State University Research Foundation, Equipment and Infrastructure Enhancement Grant, Blaber, M. (Co-P.I.) Critical Enhancements to Macromolecular X-ray Facility, $49,500 Li, H., Taylor, K., Blaber, M. and Somasundaram, T. (7/1/07-6/30/08)
12. Florida State University Research Foundation, Application Proof of Concept (GAP) Grant, Blaber, M. (P.I.), Heparin Binding Properties of Mutant FGF-1. $40,000 (8/05)
11. Florida State University Research Foundation, Cornerstone Program Enhancement Grant, Blaber, M. (P.I.), The Role of a Newly-identified Enzyme in Multiple Sclerosis and Spinal Cord Damage. $99,652 Blaber, M., Schwartz, M. and Sang, A.(4/1/02-3/31/04)
10. Florida State University, Council on Research and Creativity Planning Grant, Blaber, M. (P.I.), Structure and Function Studies of Myelencephalon-specific Protease, an Enzyme Implicated in Nerve Damage and Multiple Sclerosis. $20,000 (11/01)
9. Florida State University Research Foundation, Cornerstone Program Enhancement Grant, Blaber, M. (Co-P.I.),Program in Real-Time Electron Paramagnetic Resonance for the Life and Chemical Sciences. Fajer, P., Blaber, M., Hilinski, E., Logan, T. and Steigman, A. $100,000 (3/1/01-2/28/03)
8. Graduate Recruiting Supplement, College of Arts and Sciences, $7,000 Blaber, M. (P.I.), (12/00)
7. Florida State University Research Foundation, Cornerstone Program Enhancement Grant, Blaber, M. (Co-P.I.),Drug Development for Cystic Fibrosis. Teem, J., Blaber, M., and Logan, T. $100,000 (3/1/99-2/28/01) (Co-PI)
6. Florida State University, Distance Learning Course Development Grant, Blaber, M. (P.I.), BCH5425 Molecular Biology and Biotechnology. $8,000 (5/99)
5. Florida State University, Council on Research and Creativity Planning Grant, Blaber, M. (P.I.), Protein Engineering of 2,5-diketo-D-Gluconate Reductase - An Enzyme for Vitamin C Biosynthesis. $12,000 (5/99)
4. Florida State University, Distance Learning Course Development Grant, Blaber, M. (P.I.), CHM1045 General Chemistry I. $8,000 (11/98)
3. Florida State University, Web Based Coursework Development Summer Grant, Blaber, M. (P.I.), CHM1045 General Chemistry I. $5,200 (5/98)
2. Florida State University, Council on Research and Creativity Planning Grant, Blaber, M. (P.I.), Protease Structure and Specificity Relationships. $12,000 (11/96)
1. Florida State University, Council on Research and Creativity First Year Assistant Professor Award, Blaber, M. (P.I.), A Study of Protein Structure and Stability Relationships. $8,900 (5/95)

Book Reviews/Journals Refereed

5. Protein Structure and Function, prospectus review, Pearson Prentice Hall (2005)
4. Recombinant DNA - The Basics Series, Metzenberg, S., (review) Garland Science/BIOS Scientific Publishers (2004)
3. Molecular Biology of the Gene (5^th Edition) Watson (review, Chapter 8 - DNA Replication; Chapter 12 - Mechanisms of Transcription), Benjamin Cummings (2003)
2. Biochemistry, The Chemical Reactions of Living Cells (2^nd Edition) Metzler (review, Chapter 6 - Thermodynamics and Biochemical Equilibria), Harcourt Academic Press (2000)
1. Cases in Industry Practice for Biotechnology (review), Pearson Publishing, Livonia, MI (2000)

Protein Science, Proteins: Structure, Function and Genetics, Journal of Biological Chemistry, Biochemica et Biophysica Acta, Proceedings of the National Academy of Sciences, Journal of Molecular Biology, International Journal of Biological Macromolecules, Biochemistry, Journal of Physical Chemistry, Journal of Molecular Structure, Biochemical Journal, Crystal Growth & Design, International Journal of Biological Macromolecules, Cell Research, Acta Crystallographica Section F, European Biophysics Journal, Biological Chemistry, BioEssays, Cancer Biomarkers

Memberships in Professional Societies

American Chemical Society, Biophysical Society, Protein Society, American Association for the Advancement of Science (AAAS), Federation of American Societies for Experimental Biology (FASEB), International Union of Crystallographers (IUCr), American Society for Biochemistry & Molecular Biology (ASBMB), Clinical Chemistry

Oral Research Presentations - Invited

39. Deconstruction of a Symmetric Protein Superfold, Department of Pharmaceutical Chemistry, University of Kansas (10)
38. Human Kallikrein-related Peptidases (KLK’s): Activation Cascades and Inflammatory Demyelination, Neuroscience Symposium, Department of Psychology, FSU (10)
37. Structural Biology and Enzymology of the Human Kallikrein-related Peptidases (E.K. Frey-E. Werle Gold Medal Award), 3^rd International Symposium on Kallikreins and Kallikrein-related Peptidases, Munich, Germany (09)
36. Exploring Symmetric Protein Architecture by Structural Biology to Create an Artificial Protein, Japan Atomic Energy Agency, Tokai, Japan (09)
35. Symmetric Protein Architecture: Consequences for Protein Stability, Folding and Function, Advanced Technology Institute International Forum on Protein Structure Determination and Applications, Japan (09)
34. Activation Profiles and Regulatory Cascades of the Human Kallikrein-related Peptidases, Department of Biophysics, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Brazil (08)
33. A Logical OR Redundancy within the Asx-Pro-Asx-Gly Type I beta-turn Motif, Japan Atomic Energy Research Institute, Tokai Japan (08)
32. Opportunities in the Design of Second-Generation Protein Therapeutics, 5^th Annual Conference on Regenerative Medicine, Las Vegas (08)
31. Activation Profiles and Regulatory Cascades of the Human Kallikrein-related Peptidases (KLKs), 2nd International Symposium on Kallikreins and Kallikrein-Related Peptidases, Santorini Island, Greece (07)
30. Solvent Structure in Protein Engineering of Human Fibroblast Growth Factor-1, Workshop on Neutron Protein Crystallography and its Perspective, Hitachi City, Japan (07)
29. The Latest in Molecular Architecture: Designing New Drugs, 4^th Annual Conference on Regenerative Medicine, Las Vegas (07)
28. Protein Engineering in the Development of a Novel Angiogenic Therapy for No-Option Coronary Heart Disease Patients, Grand Rounds, College of Medicine, Florida State University (06)
27. Stability and Function in a Symmetric Protein Architecture, Department of Bioengineering, Kagoshima University, and Graduate School of Pharmaceutical Sciences, Kyushu University, Japan (06)
26. Confessions of a Molecular Architect, Ralph Alden Bradshaw 65^th Birthday Symposium, Beckman Center of the National Academy of Arts and Sciences and Engineering, University of California, Irvine (06)
25. Activation Cascades Involving the Human Kallikrein Family, Burnett College of Biomedical Sciences, University of Central Florida (05)
24. DSC: Data Analysis, Current Trends in Microcalorimetry, Boston MA (05)
23. Tertiary and Primary Structure Symmetry in Protein Evolution and Design, Department of Physiology and Biophysics, College of Medicine, UC Irvine (05)
22.The Role of Turn Regions in Protein Structure, Stability and Folding, Amgen Corp, Thousand Oaks CA (05)
21. Structure and Function Study of Human Kallikreins, Department of Biomedical Sciences, College of Medicine, Florida State University (05)
20. Solvent Structure in the Active Site of Human Kallikrein 1: A Ghost in the Machine, International Workshop on Hydrogen and Hydration in Proteins and Nucleic Acids, January 17-18, 2005 University of Tokyo, Japan
19. Kallikrein 6 and Inflammatory Demyelinating Disease, Dyax Corp., Boston MA (05)
18. Protein Symmetry, Stability and Function, CALCON 2004 - 59^th Annual Calorimetry Conference, Santa Fe NM (04)
17. Structural Biology of Human Kallikreins 6 and 1, Department of Pathology, Mount Sinai Hospital, Toronto, Ontario Canada (04)
16. Structural Symmetry in Protein Evolution and Design, Department of Chemistry, Gettysburg College (04)
15. Structure and Function of Myelencephalon-specific Protease/Kallikrein 6: A Novel Serine Protease Expressed in the CNS and Implicated in Demyelinating Disease, The Blueprint of MS, MS Society, North Florida Chapter, Tallahassee Community College, FL (04)
14. Structure and function studies of myelencephalon-specific protease (MSP)/kallikrein 6, Mayo Clinic, Jacksonville FL (04)
13. Structural Symmetry in a b-Trefoil - Implications for Protein Evolution and Design, Department of Chemistry & Biochemistry, Florida State University (04); School of Natural Sciences, U.C. Merced (03); Matthews Symposium, Eugene, OR (03)
12. Metabolic and Protein Engineering in the Development of a New Method for the Production of Vitamin C, Southeast Regional Meeting of the American Society for Microbiology, Gainesville, FL (02)
11. DSC, isothermal equilibrium and folding kinetics of FGF - getting it all to agree, Trends in Biocalorimetry: Applications and Answers, Sealy Center for Structural Biology, UTMB Galveston, TX (02); Current Trends in Biocalorimetry, North Carolina Biotechnology Center , NC (02)
10. Structure and Function of Myelencephalon-specific Protease/Human Kallikrein 6: A Novel Serine Protease Expressed in the CNS and Implicated in Demyelinating Disease, Berlex Biosciences (02)
9. Crystal Packing Effects upon Protein Structures determined by X-ray Crystallography. 223^rd American Chemical Society Meeting (02)
8. Structural Assembly of the Active Site in an Aldo-keto Reductase by NADPH Cofactor, Georgia State University Chemistry Seminar Series (02)
7. Stability and Dynamics Issues in Enzyme Engineering of an Aldo-keto Reductase. SERMACS 2001, Savannah GA (01)
6. The Role of Low Concentrations of Guanidine HCl in Reversible Denaturation of Human FGF-1. Sturtevant Biothermodynamics Symposium, Tallahassee FL (99), American Chemical Society Florida Division, Orlando FL (99)
5. Metabolic and Protein Engineering in the Development of a New Method for the Production of Vitamin C. Florida Institute of Technology (99), Florida State University (98)
4. Structure, Stability and Function of Human Acidic Fibroblast Growth Factor. Kirin Central Laboratory for Key Technology, Yokohama Japan (98), Sagami Chemical Research Center, Sagamihara Japan (98), International Institute for Advanced Research, Seika Japan (98)
3. Metabolic Engineering for the Production of Vitamin C: The Structure of 2,5-Diketo-D-Gluconate Reductase. Millsaps College (97), University of South Florida (97)
2. Mechanisms of Regulation of Human Acidic Fibroblast Growth Factor. 20^th Annual Research Seminar American Cancer Society, Florida Division (97)
1. Protein Structure, Stability and Function. Clarkson University (96)

Oral Research Presentations - Contributed

6. A Logical OR Redundancy within the Asx-Pro-Asx-Gly Type I beta-turn Motif, Northwest Crystallography Workshop (NWCW), Eugene OR (08)
5. 1.70Å X-ray structure of human apo kallikrein 1: Structural changes upon peptide inhibitor/substrate binding, 1st International Conference on Kallikreins, Lausanne Switzerland (05)
4. The Role of Symmetry in Protein Folding and Design. Florida Annual Meeting and Exposition of the American Chemical Society (01)
3. Modulation of Protein Stability. Florida Annual Meeting and Exposition of the American Chemical Society (97)
2. Denaturation Studies of Human Acidic Fibroblast Growth Factor. First International Conference on the Applications of Biocalorimetry (96)
1. Protein Stability as a Regulatory Mechanism. Florida Annual Meeting and Exposition of the American Chemical Society (95)

Peer-Reviewed Publications - Principal Investigator

77. Substrate specificity and inhibition of human kallikrein-related peptidase 3 (KLK3 or PSA) activated with sodium citrate and glycosaminoglycans., Andrade, D., Assis, D.M., Lima, A.R., Oliveira, J.R., Araujo, M.S., Blaber, S.I., Blaber, M., Juliano, M.A. and Juliano, L., Arch. Biochem. Biophys. 498, 74-82 (2010)
76. Functional intersection of the Kallikrein-related peptidases (KLKs) and thrombostasis axis, Blaber, M., Yoon, H., Juliano, M.A., Scarisbrick, I.A., and Blaber, S.I., Biological Chemistry 391, 311-320 (2010)

75. Analysis of the Dynamics of Assembly and Structural Impact for a Histidine Tagged FGF-1 – 1.5 nm Au Nanoparticle Bioconjugate, Kogot, J.M., Parker, A.M., Lee, J., Blaber, M., Strouse, G.F. and Logan, T.M., Bioconjugate Chemistry 20, 2106–2113 (2009)
74. X-ray Structure and Biophysical Properties of Rabbit Fibroblast Growth Factor-1, Lee, J., Blaber, S.I., Irsigler, A., Aspinwall, E. and Blaber, M., Acta Cryst. F. 65, 1097-1104 (2009)

73. Engineering an Improved Crystal Contact across a Solvent-Mediated Interface of Human Fibroblast Growth Factor-1, Meher, A.K., Blaber, S.I., Lee, J., Honjo, E., Kuroki, R. and Blaber, M., Acta Cryst. F. 65, 1136-1140 (2009)
72. Structural Basis of Conserved Cysteine in the Fibroblast Growth Factor Family: Evidence for a Vestigial Half-cystine, Lee, J. and Blaber, M., J. Mol. Biol. 393, 128-139 (2009)

71. The Interaction between Thermodynamic Stability and Buried Free Cysteines in Regulating the Functional Half-life of Fibroblast Growth Factor-1, Lee, J. and Blaber, M., J. Mol. Biol. 393, 113-127 (2009)

70. A Completed KLK Activome Profile: Investigation of Activation Profiles of KLK9, 10 and 15, Yoon, H., Blaber, S.I., Debela, M., Goettig, P., Scarisbrick, I.A. and Blaber, M., Biological Chemistry 390, 373-377 (2009)

69. S1 and S2 Subsite Specificities of Human Plasma Kalikrein and Tissue Kallikrein 1 on the Hydrolysis of Peptides Derived from Bradykinin Domain of Human Kininogen., Lima, A.R., Alves, F.M., Angelo, P.F., Andrade, D., Blaber, S.I., Blaber, M., Juliano.L. and Juliano, M.A., Biological Chemistry 389, 14871494 (2008)

68. Protease Activated Receptor Dependent and Independent Signaling by Kallikreins 1 and 6 in CNS Neuron and Astroglial Cell Lines, Vandell, A.G., Larson, N., Laxmikanthan, G., Panos, M., Blaber, S.I., Blaber, M. and Scarisbrick, I.A., J. Neurochem. 107, 855-870 (2008)

67. Activation Profiles of Human Kallikrein-related Peptidases by Proteases of the Thrombostasis Axis, Yoon, H., Blaber, S.I., Evans, D.M., Trim, J., Juliano, M.A., Scarisbrick, I.A. and Blaber, M. Prot. Sci. 17, 1998-2007 (2008)

66. Kallikreins are Associated with Secondary Progressive Multiple Sclerosis and Promote Neurodegeneration, Scarisbrick, I.A., Linbo, R., Vandell, A.G., Keegan, M., Blaber, S.I., Blaber, M., Sneve, D., Lucchinetti, C.F., Rodriguez, M. and Diamandis, E., Biol. Chem. 389, 739-745 (2008)

65. Mutagenesis of the crystal contact of acidic fibroblast growth factor, Honjo, E., Tamada, T., Adachi, M., Kuroki, R., Meher, A. and Blaber, M., J. Synchrotron Radiation 15, 285-287 (2008)

64. The Substrate Specificity of Human Kallikrein 1 and 6 Determined by Phage Display, Li, H.-X., Hwang, B.-Y., Laxmikanthan, G., Blaber, S.I., Blaber, M., Golubkov, P.A., Ren, P., Iverson, B.L. and Georgiou, G. Protein Science 17, 664-672 (2008)

63. A Logical OR Redundancy within the Asx-Pro-Asx-Gly Type I b-turn Motif, Lee, J., Dubey, V.K., Longo, L.M. and Blaber, M. J. Mol. Biol. 377, 1251-1264 (2008)

62. Activation Profiles and Regulatory Cascades of the Human Kallikrein-related Peptidases, Yoon, H., Laxmikanthan, G., Lee, J., Blaber, S.I., Rodriguez, A., Kogot, J.M., Scarisbrick. I.A. and Blaber, M., J. Biol. Chem. 282, 31852-31864 (2007)

61. Spackling the Crack: Stabilizing Human Fibroblast Growth Factor-1 by Targeting the N- and C-terminus b-strand Interactions, Dubey, V.K., Lee, J., Somasundaram, T., Blaber, S. and Blaber, M., J. Mol. Biol. 371, 256-268 (2007)

60. The Autolytic Regulation of Human Kallikrein-Related Peptidase 6, Blaber, S., Yoon, H., Scarisbrick, I.A., Juliano, M.A., and Blaber, M. Biochemistry 46, 5209-5217 (2007)

59. Proteinase-activated Receptors (PARS): Targets for Kallikrein Signalling, Oikonomopoulou, K., Hansen, K.K., Saifeddine, M., Tea, I., Blaber, M., Blaber, S.I., Scarisbrick, I.A., Andrade-Gordon, P., Cottrell, G.S., Bunnett, N.W., Diamandis, E.P. and Hollenberg, M.D., J. Biol. Chem. 281, 32095-32112 (2006)

58. Dynamic Role of Kallikrein 6 in Traumatic Spinal Cord Injury, Scarisbrick, I.A., Sabharwal, P., Blaber, S.I., Cruz, H., Ameednuddin, S., Papke, L.M., Larsen, N., Fehlings, M.G., Reeves, R.K., Blaber, M., Windebank, A.J. and Rodriguez, M., Eur. J. Neurosci. 24, 1457-1469 (2006)

57. Potential Scope of Action of Tissue Kallikreins in CNS Immune-Mediated Disease, Scarisbrick, I.A., Blaber, S.I., Tingling, J.T., Rodriguez, M., Blaber, M, and Christophi, G.P., J. Neuroimmunol. 178, 167-176 (2006)

56. Kallikrein-Mediated Cell Signaling: Targeting Proteinase-Activated Receptors (PARs)1, Oikonomopoulou, K., Hansen, K.K., Saifeddine, M., Vergnolle, N., Tea, I., Blaber, M., Blaber, S.I., Scarisbrick, I., Diamandis, E.P. and Hollenberg, M.D. Biological Chemistry 387, 817-824 (2006)

55. A comprehensive nomenclature for serine proteases with homology to the tissue kallikrein, Lundwall, A Band, V., Blaber, M., Clements, J., Courty, Y., Diamandis, E., Lilja, H., Maltais, L.J., Olsson, Y., Petraki, C., Sotiropoulou, G., Stenman, U.-H., Stephan, C., Talieri, M. and Yousef, G. Biological Chemistry 387, 637-641(2006)

54. Substrate Specificity of Human Kallikrein 6: Salt and Glycosaminoglycan Activation Effects, Angelo, P.F., Lima, A.R., Alves, F.M., Juliano, L., Blaber, S.I., Scarisbrick, I.A., Blaber, M. and Juliano, M.A. J. Biol. Chem. 281, 3116-3126 (2006)

53. Conversion of type I 4:6 to 3:5 b-turn Types in Human Acidic Fibroblast Growth Factor: Effects upon Structure, Stability, Folding and Mitogenic Function, Lee, J., Dubey, V.K., Somasundaram, T. and Blaber, M. Proteins 62, 686-697(2006)

52. Redesigning Symmetry-Related “Mini-Core” Regions of FGF-1 to Increase Primary Structure Symmetry: Thermodynamic and Functional Consequences of Structural Symmetry, Dubey, V.K., Lee, J. and Blaber, M., Protein Science 14:2315-2323 (2005)

51. 1.7Å X-ray Structure of Apo Human Kallikrein 1: Structural Changes upon Peptide Inhibitor/substrate Binding, Laxmikanthan, G., Blaber, S.I., Bernett, M.J., Scarisbrick, I.A., Juliano, M.A. and Blaber, M., Proteins 58, 802-814 (2005)

50. Sequence-Swapping does not Result in Conformation-Swapping for the b4/b5 and b8/b9 b-Hairpin Turns in Human Acidic Fibroblast Growth Factor, Kim, J., Lee, J., Brych, S.R., Logan, T.M. and Blaber, M. Protein Science 14, 351-359 (2005)

49. Structural and Energetic Consequences of Mutations in a Solvated Hydrophobic Cavity, Adamek, D.H., Guerrero, L., Blaber, M. and Caspar, D.L.D. J. Mol. Biol. 346, 307-318 (2005)

48. Distinct Promoters Regulate Tissue-specific and Differential Expression of Kallikrein 6 in CNS Demyelinating Disease, Christophi, G.P., Isackson, P.J., Blaber, S., Blaber, M., Rodriguez, M. and Scarisbrick, I.A. Journal of Neurochemistry 91, 1439-1449 (2004)

47. Symmetric Primary And Tertiary Structure Mutations Within A Symmetric Superfold: A Solution, Not A Constraint, To Achieve A Foldable Polypeptide, Brych, S.R., Dubey, V.K., Bienkiewicz, E., Lee, J., Logan, T.M. and Blaber, M., J. Mol. Biol. 344, 769-780 (2004)

46. An Atomic Resolution Structure for Human Fibroblast Growth Factor-1, Bernett, M.J., Somasundaram, T. and Blaber, M. Proteins: Structure, Function and Bioinformatics 57, 626-634 (2004) Cover article

45. Targeting Kallikrein 6 Proteolysis Attenuates CNS Inflammatory Demyelinating Disease, Blaber, S., Ciric, B., Bernett, M., Blaber, M., Rodriguez, M. and Scarisbrick, I.A., FASEB J. 18, 920-922 (2004)

44. Structural Alteration of Cofactor Specificity in Corynebacterium 2,5-diketo-D-Gluconic Acid Reductase, Sanli, G., Banta, S., Anderson, S. and Blaber, M. Protein Science 13, 504-512 (2004)
43. Accommodation of a highly symmetric core within a symmetric protein superfold, Brych, S.R., Kim, J., Logan, T.M. and Blaber, M., Protein Science 12, 2704 - 2718 (2003) Cover article
42. Identification of a key structural element for protein folding within b-hairpin turns, Kim, J., Brych, S.R., Lee, J., Logan, T.M. and Blaber, M., J. Mol. Biol. 328, 951 - 961 (2003)
41. Structural Biology of the Aldo-keto Reductase Family of Enzymes: Catalysis and Cofactor Binding, Sanli, G., Dudley, J.I. and Blaber, M., Cell Biochem. Biophys. 38, 79-101 (2003)
40. Crystal Structure and Biochemical Characterization of Human Kallikrein 6 Reveals a Trypsin-like Kallikrein is Expressed in the Central Nervous System, Bernett, M.J., Blaber, S.I., Scarisbrick, I.A., Dhanarajan, P., Thompson, S.M., and Blaber, M. J. Biol. Chem 277, 24562-24570 (2002)
39. Activity of a Newly Identified Serine Protease in Oligodendrocyte Biology and Demyelination, Scarisbrick, I.A., Blaber, S.I., Lucchinetti, C.F., Genain, C.P., Blaber, M. and Rodriguez, M.. Brain 125, 1-14 (2002)
38. Alternative Type I and I' Turn Conformations in the b8/b9 b-hairpin of Human Acidic Fibroblast Growth Factor, Kim, J., Blaber, S.I.,. and Blaber, M. Protein Science 11, 459-466 (2002)
37. Characterization of Recombinant Rat Myelencephalon Specific Protease, Blaber, S.I., Scarisbrick, I.A., Bernett, M.J., Dhanarajan, P., Seavy, M.A., Jin, Y., Schwartz, M.A., Rodriguez, M. and Blaber, M. Biochemistry 41, 1165-1173 (2002)
36. Structure and Stability Effects of Mutations Designed to Increase the Primary Sequence Symmetry within the Core Region of a b-Trefoil , Brych, S.R., Blaber, S.I., Logan, T.M. and Blaber, M., Protein Science 10, 2587-2599 (2001)
35. An Efficient, Flexible-Model Program for the Analysis of Differential Scanning Calorimetry Data , Grek, S., Davis, J. and Blaber, M. Protein and Peptide Letters 6, 429-436 (2001)
34. Active Site Organization in an Aldo-keto Reductase by NADPH Cofactor, Sanli, G. and Blaber, M., Journal of Molecular Biology 309, 1209-1218 (2001)
33. Reduction of Wobble-position GC Bases in Corynebacteria Genes and Enhancement of PCR and Heterologous Expression, Sanli, G., Blaber, S.I. and Blaber, M. Journal of Molecular Microbiology and Biotechnology 3, 123-126 (2001)
32. Thermodynamic Characterization of Mutants of Human FGF-1 with an Increased Physiological Half-life, Culajay, J.F., Blaber, S.I., Khurana, A. and Blaber, M. Biochemistry 39, 7153-7158 (2000)
31. Preferential Expression of Myelencephalon Specific Protease by Oligodendrocytes of the Adult Rat Spinal Cord White Matter, Scarisbrick, I.A., Asakura, K., Blaber, S., Blaber, M., Isackson, P.J., Bieto, T., Rodriguez, M. and Windebank, A.J. Glia 30, 219-230 (2000)
30. Molecular Modeling of Substrate Binding in Wild Type and Mutant Corynebacteria 2,5-Diketo-D-Gluconate Reductase, Khurana, S., Sanli, G., Powers, D.B., Anderson, S.A. and Blaber, M. Proteins: Structure, Function and Genetics 39, 68-75 (2000)
29. The Role of Low Concentrations of Guanidine HCl in Reversible Thermal Denaturation of Human FGF-1, Blaber, S.I., Culajay, J.F., Khurana, A. and Blaber, M. Biophysical Journal 77, 470-477 (1999)
28. Disordered water within a hydrophobic protein cavity visualized by x-ray crystallography, Yu, B., Blaber, M., Gronenborn, A.M., Clore, G.M. and Caspar, D.L.D. Proceedings of the National Academy of Sciences 96, 103-108 (1999)
27. Crystal Structure of 2,5-diketo-D-gluconate Reductase A Complexed with NADPH at 2.1Resolution, Khurana, S., Powers, D.B., Anderson, S.A. and Blaber, M. Proceedings of the National Academy of Sciences 95, 6768-6773 (1998)
26. Preliminary x-ray crystallographic analysis and molecular replacement studies with 2,5-diketo-gluconate reductase, Khurana, S., Powers, D.B., Anderson, S. and Blaber, M. Protein and Peptide Letters 4, 287-290 (1997)
25. Crystallization and Preliminary X-ray Analysis of Mouse Pro-Renin Converting Enzyme, Blaber, M. Protein and Peptide Letters 4, 207-210 (1997)
24. X-ray Crystal Structure of Human Acidic Fibroblast Growth Factor, Blaber, M., DiSalvo, J. and Thomas, K.A. Biochemistry 35, 2086-2094 (1996)

Peer-Reviewed Publications - Postdoctoral Fellow

23. Alanine Scanning Mutagenesis in the Helix 115-123 of Phage T4 Lysozyme: Effects upon Structure, Stability and Solvent Accessibility, Blaber, M., Baase, W.A., Gassner, N. and Matthews, B.W. J. Mol. Biol. 246, 317-330 (1995)
22. Determination of a-helix Propensity within the Context of a Folded Protein: Sites 44 and 131 in Bacteriophage T4 Lysozyme, Blaber, M., Zhang, X.-J., Lindstrom, J.D., Pepiot, S.D., Baase, W.A. and Matthews, B.W. J. Mol. Biol. 235, 600-624 (1994)
21. Accomodation of Amino Acid Insertions in an a-Helix of T4 Lysozyme: Structural and Thermodynamic Analysis, Heinz, D.W., Baase, W.A., Zhang, X.-J., Blaber, M., Dahlquist, F.W. and Matthews, B.W. J. Mol. Biol. 236, 869-886 (1994)
20. Energetic Cost and Structural Consequences of Burying a Hydroxyl Group within the Core of a Protein Determined from Ala->Ser and Val->Thr Substitutions in T4 Lysozyme, Blaber, M., Lindstrom, J.D., Gassner, N., Xu, J., Heinz, D.W. and Matthews, B.W. Biochemistry 32, 11363-11373 (1993)
19. Structural Basis of Amino Acid a Helix Propensity, Blaber, M., Zhang, X.-J. and Matthews, B.W. Science 260, 1637-1640 (1993)
18. Response of a Protein Structure to Cavity-Creating Mutations and Its Relation to the Hydrophobic Effect, Eriksson, A.E., Baase, W.A., Zhang, X.-J., Heinz, D.W., Blaber, M., Baldwin, E.P. and Matthews, B.W. Science 255, 178-183 (1992)
17. Dissection of Protein Structure and Folding by Directed Mutagenesis, Baase, W.A., Eriksson, A.E., Zhang, X.-J., Heinz, D.W., Sauer, U., Blaber, M., Baldwin, E.P., Wozniak, J.A. and Matthews, B.W. Faraday Discuss. 93, 173-181 (1992)

Peer-Reviewed Publications - Graduate Student

16. Synthetic Chimeras of Mouse Growth Factor-associated Glandular Kallikreins. I. Kinetic Properties, Blaber, M., Isackson, P.J., Burnier, J.P., Marsters, J.C.Jr. and Bradshaw, R.A. Prot. Sci. 2, 1210-1219 (1993)
15. Synthetic Chimeras of Mouse Growth Factor-associated Glandular Kallikreins. II. Growth Factor Binding Properties, Blaber, M., Isackson, P.J., Holden, H.M. and Bradshaw, R.A. Prot. Sci. 2, 1220-1228 (1993)
14. Prediction of the Three-dimensional Structures of the Nerve Growth Factor and Epidermal Growth Factor Binding Proteins (Kallikreins) and an Hypothetical Structure of the High Molecular Weight Complex of Epidermal Growth Factor with its Binding Protein, Bax, B., Blaber, M., Ferguson, G., Sternberg, M.J.E. and Walls, P.H. Prot. Sci. 2, 1229-1241 (1993)
13. Structure and Function Analyses of Growth Factor Associating Murine Glandular Kallikreins, Blaber, M. Ph.D. Thesis, University of California, Irvine CA (1990)
12. The Characterization of Recombinant Mouse Glandular Kallikreins from E. coli, Blaber, M., Isackson, P.J. and Bradshaw, R.A. Proteins: Struct. Funct. Genet. 7, 280-290 (1990)
11. The Protease Inhibitory Properties of the Alzheimer's Beta-Amyloid Precursor Protein, Sinha, S., Dovey, H.F., Seubert, P., Ward, P.J., Blacher, R.W., Blaber, M., Bradshaw, R.A., Arici, M., Mobley, W.C. and Lieberburg, I. J. Biol. Chem. 265, 8983-8985 (1990)
10. Substrate Specificities of Growth Factor Associated Kallikreins of the Mouse Submandibular Gland, Blaber, M., Isackson, P.J., Marsters, J.C. Jr., Burnier, J.P. and Bradshaw, R.A. Biochemistry 28, 7813-7819 (1989)
9. A Complete cDNA for the Major Epidermal Growth Factor Binding Protein in the Male Mouse Submandibular Gland, Blaber, M., Isackson, P.J. and Bradshaw, R.A. Biochemistry 26, 6742-6749 (1987)
8. Epidermal Growth Factor Binding Protein: A Model Serine Protease for Enzyme Engineering, Blaber, M., Blevins, R.A., Thomas, K.A., Isackson, P.J. and Bradshaw, R.A. Protein Structure, Folding and Design 2., D. Oxender, ed., Alan R. Liss, Inc., (1987)
7. Epidermal Growth Factor Binding Protein: Identification of a Different Protein, Isackson, P.J., Silverman, R.E., Blaber, M., Server, A.C., Nichols, R.A., Shooter, E.M. and Bradshaw, R.A. Biochemistry 26, 2082-2085 (1987)
6. Complete Nucleotide Sequence of the Escherichia coli Gene Encoding Malate Dehydrogenase, McAlister-Henn, L., Blaber, M., Bradshaw, R.A. and Nisco, S.J. Nucl. Acids Res. 15, 4993 (1987)

Peer-Reviewed Publications - Research Technician

5. Purification and Characterization of Single-Chain Urokinase from E. coli, Winkler, M.E. and Blaber, M. Biochemistry 25, 4041-4045 (1986)
4. Activation of Plasminogen by Pro-Urokinase. I. Mechanism, Lijnen, H.R., Zamarron, C., Blaber, M., Winkler, M.E. and Collen, D. J. Biol. Chem. 261, 1253-1258 (1986)
3. Purification and Characterization of Recombinant Urokinase from E. coli, Winkler, M.E., Blaber, M., Bennet, G.L., Holmes, W.E. and Vehar, G.A. Nature Biotechnology 3, 990-1000 (1985)
2. Cloning and Expression of the Gene for Pro-Urokinase in Escherichia Coli, Holmes, W.E., Pennica, D., Blaber, M., Rey, M.W., Gunzler, W.A., Steffens, G.J. and Heyneker, H.L. Nature Biotechnology 3, 923-929 (1985)
1. Biological and Thrombolytic Properties of Proenzyme and Active Forms of Urokinase III: Thrombolytic Properties of Natural and Recombinant Urokinase in Rabbits with Experimental Jugular Vein Thrombosis, Collen, D., Stassen, J.M., Blaber, M., Winkler, M.E. and Verstraete, M. Thromb. Haemostasis 52, 27-30 (1984)

Book Chapters and Other Publications

13. The Essential Need for Protein Chemists, Blaber, M., Journal of Proteins and Proteomics, 1, 1-2 (2010)

12. Solvent Structure in the Active Site of Human Kallikrein 1, Laxmikanthan, G., Blaber, S.I., Scarisbrick, I.A. and Blaber, M., Hydrogen- and Hydration-Sensitive Structural Biology, Niimura, N., Mizuno, H., Helliwell, J. and Westhof, E., Eds., Kubapro, Co. Ltd Publishers, Tokyo Japan (2005) Ch. 3-6, 175-183

11. Engineering Allostery via Tandem Duplication and Turn Energetics, Blaber, M. Trends in Biotechnology 22, 1-2 (2004)

10. The Role of the Turn Symmetry in the Folding and Stability of FGF-1, Lee, J., Kim, J., Blaber, M. and Logan, T. National High Magnetic Field Laboratory Reports 10, 11-13 (2003)
9. Myelencephalon-specific Protease, Scarisbrick, I.A., Blaber, S. and Blaber, M., Handbook of Proteolytic Enzymes, 2^nd Ed., Vol 1-2, pp1587-1590, Barrett, A.J., Rawlings, N.D., and Woessner, J.F., Eds., Elsevier Ltd., London (2003)
8. Protein Thermal Characterization and Parameter Analysis: A Rapid, Flexible Analysis on the Windows Platform, Grek, S., Davis, J.K., and Blaber, M. Thirty-Second Southeastern Symposium on System Theory Proceedings, Roberts, R.G. and Simons, F.O., Jr., Eds. (2000) pp. 41-45
7. Denaturation Studies of Human Acidic Fibroblast Growth Factor, Adamek, D., Popovic, A., Blaber, S. and Blaber, M. Biocalorimetry: Applications of Calorimetry in the Biological Sciences, John Wiley & Sons, Ladbury, J.E. and Haq, I., Eds. (1998) Chapter 16, pp 235-241
6. Contribution of Free Cysteine Residues to the Stability of Human Acidic Fibroblast Growth Factor, Popovic, A., Adamek, D., Blaber, S. and Blaber, M. Biocalorimetry: Applications of Calorimetry in the Biological Sciences, John Wiley & Sons, Ladbury, J.E. and Haq, I., Eds. (1998) Chapter 20, pp 277-282
5. Biophysical and Structural Analysis of Human Acidic Fibroblast Growth Factor, Blaber, M., Adamek, D.H., Popovic, A. and Blaber, S.I. Techniques in Protein Chemistry VIII, Academic Press, Marshak, D.R., Ed. 745-753 (1997)
4. Glandular Kallikreins as Growth Factor Processing Enzymes, Blaber, M., Isackson, P.J. and Bradshaw, R.A. Growth Regulation and Carcinogenesis, Vol II, Paukovits, W.R., Ed., CRC Press, Inc. (1991)
3. Neurotrophic Factors in the CNS: Biosynthetic Processing and Functional Responses, Bradshaw, R.A., Altin, J.G., Blaber, M., Cavanaugh, K.P., Eveleth, D.D., Kornblum, H.I., Leslie, F.M. and Raffioni, S., Progress in Brain Research, Vol. 86, P. Coleman, G. Higgins and C. Phelps, eds. Elsevier Science Publishers B.V. (1990)
2. Purification of the Nerve Growth Factor Receptor, Blaber, M., Eveleth, D.D. and Bradshaw, R.A. Nerve Growth Factors, Vol 12, R.A. Rush ed., IBRO Handbook Series: Methods in the Neurosciences 279-298 (1989)
1. Neurotrophic Factors of the Central Nervous System: Synthesis and Activities, Bradshaw, R.A., Blaber, M., Cavanaugh, K., Eveleth, D.D., Isackson, P.J., Kornblum, H.I. Leslie, F., Morrison R.S, Schwarz, M. and Sharma, A. Symposia In Neuroscience, Volume 7: Neuronal Plasticity and Trophic Factors. G. Biggio, P.F. Spano, G. Toffano, S.H. Appel and G.L. Gessa, eds. Springer Verlag/Liviana Press (1988)

Abstracts - Principal Investigator

114. Salt and glycosaminoglycan effects on substrate specificity of human kallikrein 3 (hKLK3) and 13 (hKLK13), Andrade, d., Lima, A.R., Assis, D.M., Angelo, P.F., Alves, F.M., Blaber, S.I., Blaber, M., Juliano, M.A. and Juliano, L., 3^rd International Symposium on Kallikreins & Kallikrein-related Peptidases, 47 (2009)

113. Regulation and function of kallikrein related peptidase 6 in malignant melanomas, Krenzer S., Klucky B., Mauch C., Blaber M., Angel P., and Hess J., 3^rd International Symposium on Kallikreins & Kallikrein-related Peptidases, 37 (2009)

112. Structural biology and enzymology of the human kallikrein-related peptidases, Blaber, M., Yoon, H., Lee, J., Scarisbrick, I.A., Debela, M., Goettig, P. and Blaber, S., 3^rd International Symposium on Kallikreins & Kallikrein-related Peptidases, 25 (2009)

111. Kallikrein mediated signaling in CNS neurons and astrocytes, A. G. Vandell, J. E. Burda, N. Larson, J. Wu, P. Angelo, S. I. Blaber, M. Blaber, Scarisbrick, I. A. Society for Neuroscience (2009)

110. Association of Kallikreins with Neuron Loss and Progressive Multiple Sclerosis, Linbo, R.A., Vandell, A.G., Larson, N.S., Keegan, M.B., Blaber, S.I., Blaber, M., Sneve, D.M., Lucchinetti, C.F., Rodriguez, M., Diamandis, E.P. Scarisbrick, I.A., 133rd American Neurological Association Meeting, Utah (2008)
109. A logical OR redundancy within the Asx-Pro-Asx-Gly type I b-turn motif, Lee, J., Dubey, V., Longo, L., and Blaber, M., Protein Science, 17 (suppl. 1), 232 (2008)
108. The autolytic regulation of human kallikrein-related peptidase 6 is negative feedback inhibition, Blaber, S., Yoon, H., Scarisbrick, I., Juliano, M., and Blaber, M., Protein Science, 17 (suppl. 1), 97 (2008)
107. Activation profiles and regulatory cascades of the human kallikrein-related peptidases, Yoon, H., Laxmikanthan, G., Lee, J., Blaber, S., Rodriguez, A., Kogot, J. and Blaber, M., Protein Science, 17(suppl. 1), 96 (2008)
106. De novo protein design technique in cardiovascular heart disease: expanding to a systematic approach, Smith, A., Russo, C., Nymeyer, H., Blaber, M., Fenley, M.O., FLACS LXI, 84 (2008)
105. The autolytic regulation of human kallikrein-related peptidase 6 is negative feedback inhibition, Blaber, S.I., Yoon, H., Scarisbrick, I.A., Juliano, M.A., and Blaber, M. 2^nd International Symposium on Kallikreins & Kallikrein-related Peptidases, 57 (2007)
104. The first screening method to identify potential activation for the human kallikrein family, Yoon, H., Laxmikanthan, G., Lee, J., Blaber, S.I., Rodriguez, A., Kogot, J.M., Scarisbrick, I.A., and Blaber, M., 2^nd International Symposium on Kallikreins & Kallikrein-related Peptidases, 54 (2007)
103. Multiple human tissue Kallikreins are regulated by lympho-epithelial Kazal-type inhibitor and digest desmoglein 1, Borgono, C. A., Michael, I. P., Komatsu, N., Sotiropoulou, G., Jayakumar, A., Wu, H., Clayman, G. L., Blaber, S. I., Blaber, M., Mikolajczyk, S. D., Diamandis, E. P., Journal Of Investigative Dermatology 126: 60-60 359 Suppl. 1 (2006)
102. 1.70Å X-ray structure of human apo kallikrein 1: structural changes upon peptide inhibitor/substrate binding, Laxmikanthan, G., Blaber, S.I., Bernett, M.J., Scarisbrick, I.A., Juliano, M.A. and Blaber, M., 1^st International Symposium on Kallikreins, 45 (2005)
101. Kallikreins and cell signaling: differential regulation of proteinase-activated receptors (PARS), Oikonomopoulou, K., Hansen, K.K., Saifeddine, M., Vergnolle, N., Tea, I., Blaber, M., Blaber, S.I., Scarisbrick, I., Diamandis, E.P., and Hollenberg, M.D., 1^st International Symposium on Kallikreins, 53 (2005)
100. Hydrogen and Hydration DataBase for Bio-Macromolecules (HHDB), Kuroki, R., Chatake, T., Kurihara, K., Ohhara, T., Umino, H., Cachau, R.E., Blaber, M. and Niimura, N. Acta cryst. A61, C481 (2005)
99. Redesigning the "mini-core" regions of FGF-1 to increase primary structure symmetry, Dubey, V.K. and Blaber, M. Prot. Sci. 14 (suppl. 1):175 (2005)
98. A novel method to characterize the activation of serine proteases using hybrid bait protein, Laxmikanthan, G., Kogot, J., Blaber, S.I. and Blaber, M. Prot. Sci. 14(suppl. 1):167 (2005)
97. Effect of beta-hairpin conformations on protein stability and folding kinetics, Lee, J. and Blaber, M. Prot. Sci. 14(suppl. 1):106 (2005)
96. Tissue-specific expression and differential regulation of multiple kallikrein 6 transcripts in CNS demyelinating disease,.Christophi, G.P., Isackson, P.J., Blaber, S.I., Blaber, M., Rodriguez, M. and Scarisbrick, I.A. 36th Annual Soc. Neurosci. 936.12 (2004)
95. 1.7Å X-ray structure of apo human kallikrein 1: Evidence for an induced-fit basis of dual substrate specificity, Laxmikanthan, G., Blaber, S.I., Bernett, M.J., Scarisbrick, I.A., Juliano, M.A. and Blaber, M. Gordon Research Conference, Proteolytic Enzymes and Their Inhibitors (2004 )
94. Protein symmetry, stability and function, Dubey, V.K., Brych, S.R., Lee, J. and Blaber, M, CALCON 2004 - the 59^th Annual Calorimetry Conference, 27 (2004)
93. Structure, stability and functional studies of 2,5-diketo-D-gluconate reductases, Blaber, M., Dudley, J. and Sanli, G., American Heart Association Research Symposium, 5 (2003)
92. Structural symmetry in a b-trefoil superfold , Brych, S.R., Kim, J., Logan, T.M. and Blaber, M., New Horizons in Molecular Sciences and Systems: An Integrated Approach, Okinawa Institute of Science and Technology Project, Cabinet Office, The Government of Japan, 55 (2003)
91. Increased primary sequence symmetry within the hydrophobic core of hFGF-1: Evidence of genetic drift, Brych, S.R., Kim, J., Logan, T.M. and Blaber, M., FLACS LVI, 20 (2003)
90. Cloning of the human kallikreins, Frost, N.A., Blaber, S.I., and Blaber, M., FLACS LVI, 19 (2003)
89. Expanded substrate specificity of human kallikrein 6 (hK6), Bernett, M.J., Blaber, S.I., Somasundaram, T. and Blaber, M., FLACS LVI, 18 (2003)
88. Thermal stability of various disulfide bond mutants of 2,5-DKGR-A, Dudley, J.I. and Blaber, M., FLACS LVI, 18 (2003)
87. Effect of turn conformational change on protein folding kinetics in human acidic fibroblast growth factor 1(hFGF-1), Lee, J., Kim, J. and Blaber, M., FLACS LVI, 18 (2003)
86. Identification of a key structural element for protein folding within b-hairpin turns, Kim, J., Brych, S.R., Lee, J., Logan, T.M. and Blaber, M., FLACS LVI, 18 (2003)
85. Molecular insights on substrate specificity of human kallikrein 1, Laxmikanthan, G., Blaber, S., Bernett, M. and Blaber, M., FLACS LVI, 17 (2003)
84. Cofactor specificity of Corynebacterium 2,5-diketo-D-gluconic acid reductase for NADP(H), Sanli, G. and Blaber, M., FLACS LVI, 16 (2003)
83. Metabolic and protein engineering in the development of a new method for the production of vitamin C, Sanli, G., Dudley, J.I. and Blaber, M., Program of the Southeastern Branch of the American Society for Microbiology A47 (2002)
82. Structure and stability effects of mutations designed to increase the primary sequence symmetry within the core region of a b-trefoil, Brych, S., Blaber, S., Logan, M. and Blaber, M., Protein Science 11 (suppl. 1), 218 (2002)
81. Crystal structure and biochemical characterization of human kallikrein 6 reveals a trypsin-like kallikrein is expressed in the central nervous system, Bernett, M.J., Blaber, S.I., Scarisbrick, I.A., Dhanarajan, P., Thompson, S.M. and Blaber, M., Protein Science 11 (suppl. 1), 137 (2002)
80. Alternative type I and I' turn conformations in the b8/b9 b-hairpin of human acidic fibroblast growth factor, Kim, J., Blaber, S.I. and Blaber, M., Protein Science 11 (suppl. 1), 80 (2002)
79. Enzymatic properties of rat myelencephalon-specific protease, Blaber, S., Scarisbrick, I., Dhanarajan, P., Bernett, M., Schwartz, M., Seavy, M., Rodriguez, M., Jin, Y. and Blaber, M., Protein Science 11 (suppl. 1), 59 (2002)
78. Crystal structure and biochemical characterization of human kallikrein 6 reveals a trypsin-like kallikrein is expressed in the central nervous system, Bernett, M.J., Blaber, S.I., Scarisbrick, I.A., Dhanarajan, P., Thompson, S.M. and Blaber , M. Gordon Research Conference, Proteolytic Enzymes and Their Inhibitors (2002 )
77. Crystal packing effects upon protein structure determined by x-ray crystallography, Blaber, M., Kim, J. and Blaber, S.., Abstracts of Papers of the American Chemical Society 223, 166-IEC Part 1 (2002)
76. Role of a newly identified serine protease in immune-mediated demyelination, Scarisbrick I.A., Blaber S.I., Blaber M., Rodriguez M., FASEB Journal 16, A591-A591 Part 1 (2002)
75. Stability and Dynamics Issues in Enzyme Engineering of an Aldo-keto Reductase, Sanili, G. and Blaber, M. SERMACS 2001, 121 (2001)
74. Alterations in Structure, Stability and Folding Kinetics Associated with an Increase in Internal Symmetry in Human Fibroblast Growth Factor 1, Brych, S., Blaber, S.I., and Blaber, M. Protein Science 10 (suppl. 2), 182 (2001)
73. Expression, Purification and in vitro Characterization of Myelencephalon Specific Protease (MSP), a Novel Serine Protease Expressed in Mammalian Central Nerve System, Blaber, S.I., Dhanarajan, P., Scarisbrick, I.A., Seavy, M., Jin, Y. and Blaber, M. Protein Science 10 (suppl. 2), 161 (2001)
72. Alternate Conformations in the beta 8/beta 9 Loop of Human Fibroblast Growth Factor 1, Kim, J., Blaber, S.I., Brych, S. and Blaber, M. Protein Science 10 (suppl. 2), 74 (2001)
71. The Role of Symmetry in Protein Folding and Design, Blaber, M., Brych, S. and Kim, J. FLACS 54, 19 (2001)
70. Expression, Purification and in vitro Characterization of Myelencephalon Specific Protease (MSP), A Novel Serine Protease Expressed in Mammalian Central Nerve System, Blaber, S., Bernett, M.J., Dhanarajan, P., Scarisbrick, I.A., Seavy, M., Jin, Y. and Blaber, M. Southeast Nerve Net, 17th Annual Meeting (2001)
69. X-ray Structure of Apo-2,5-Diketo-D-Gluconic Acid Reductase A, Sanli, G., Somasundaram, T. and Blaber, M., Biophysical Journal 80, 257 Part 2 (2001)
68. Energetics of the myosin IISH1 helix during contractility, Sale, K., Kelly, D.F., Fajer, P. and Blaber, M. Biophysical Journal 78, 1448Pos Part 2 (2000)
67. Structural Studies of Synthetic 2,5-Diketo-D-gluconic Acid Reductase Complexed with its Substrate and Oxidized Cofactor, Sanli, G. and Blaber, M. Proc. 8^th Intl. Conf. Crystal. Biol. Macromol., 202 (2000)
66. Structural Biology of the Mouse Glandular Kallikrein Family of Proteases, Kim, J., Blaber, S.I. and Blaber, M. Proc. 8^th Intl. Conf. Crystal. Biol. Macromol., 165 (2000)
65. A His-tagged form of Human Acidic Fibroblast Growth Factor with Enhanced Crystallographic Properties, Blaber, S.I. and Blaber, M. Proc. 8^th Intl. Conf. Crystal. Biol. Macromol., 121 (2000)
64. Structural Changes Associated with Mutations Designed to Probe the Role of a Symmetric Core-packing Arrangement in Human Acidic FGF, Brych, S.R., Blaber, S., Khurana, A., Blaber, M. Proc. 8^th Intl. Conf. Crystal. Biol. Macromol., 102 (2000)
63. A Rapid Accurate and Automated Windows-based Program for the Analysis of Differential Scanning Calorimetry Data, Grek, S., Davis, J. and Blaber, M. Protein Science 9 (Suppl.1) 167 (2000)
62. The Role of Post-translational Modification on the Enzyme Activity of Mouse Glandular Kallikreins, Kim, J., Blaber, S.I., and Blaber, M. Protein Science 9 (Suppl.1) 110 (2000)
61. Structure and Stability Effects of Cavity Reducing and Core Packing Mutants in Human Fibroblast Growth Factor I, Brych, S.R., Blaber, S.I., Khurana, S. and Blaber, M. Protein Science 9 (Suppl.1) 108 (2000)
60. The Effects of Cysteine Mutations on the Stability of Human Acidic FGF, Culajay, J.F., Blaber, S.I., Khurana, A. and Blaber, M. Protein Science 9 (Suppl.1) 100 (2000)
59. Increased Stability of Human FGF-1 Against Thermal Denaturation by Sulfate and Phosphate Binding, Whitten, S.T., Blaber, S.I., and Blaber, M. Protein Science 9 (Suppl.1) 94 (2000)
58. A Flexible, 2-State, Statistical Mechanics Based Model For DSC Analysis Implemented Under Windows, Grek, S., Davis, J. and Blaber, M. Proceedings of the Gibbs Symposium (2000)
57. Reversible Thermal Denaturation of Human FGF-1 Induced by Low Concentrations of Guanidine HCl, Blaber, S. I., Culajay, J.F., Khurana, A. and Blaber, M., Proceedings of the Gibbs Symposium (2000)
56. Deconvolution of Calorimetric Data for the Characterization of Protein Thermodynamic Parameters, Grek, S., Davis, J., Noble, N. and Blaber, M. Proceedings of the54th Calorimetry Conference, 154 (1999)
55. Structure and Stability Effects of Mutations Designed to Probe the Role of a Symmetric Core-packing Arrangement in Human Acidic FGF, Brych, S.R., Blaber, S., Khurana, S., Khurana, A. and Blaber, M. Proceedings of the54th Calorimetry Conference, 147 (1999)
54. Thermodynamic Characterization of Mutants of Human FGF-1 that have an Increased Physiological Half-life, Culajay, J.F., Blaber, S.I., Khurana, S., Khurana, A., Kennedy, D., Williams, K. and Blaber, M. Proceedings of the54th Calorimetry Conference, 150 (1999)
53. Construction and Characterization of a Synthetic 2,5-Diketo-D-Gluconate Reductase Gene, Sanli, G., Blaber, S., Khurana, S. and Blaber, M. Proceedings of the54th Calorimetry Conference, 164 (1999))
52. Energetics of the Myosin II SH1 Helix during Contractility, Kelly, D., Sale, K. and Blaber, M. Proceedings of the54th Calorimetry Conference, 158 (1999)
51. Structural Characterization of a Highly Thermostable Mutant of Human Acidic Fibroblast Growth Factor (FGF-1), Khurana, S., Culajay, J.F., Grek, S., Khurana, A. and Blaber, M., Protein Science 8, 125 (1999)
50. Thermodynamic Characterization of Mutants of Human FGF-1 that have an Increased Physiological Half-life, Culajay, J.F., Blaber, S.I., Khurana, S., Khurana, A., Kennedy, D. and Blaber, M. Protein Science 8, 95 (1999)
49. The Role of Low Concentrations of Guanidine HCl in Reversible Thermal Denaturation of Human FGF-1, Blaber, S.I., Culajay, J.F., Khurana, A. and Blaber, M. Protein Science 8, 96 (1999)
48. Construction and Characterization of a Synthetic Gene for 2,5-Diketo-D-Gluconate Reductase, Sanli, G., Blaber, S., Khurana, S. and Blaber, M. Protein Science 8, 65 (1999)
47. The Role of Low Concentrations of Guanidine HCl in Reversible Thermal Denaturation of Human Fibroblast Growth Factor-1, Blaber, M., Blaber, S.I., Culajay, J.F., and Khurana, A. FLACS 52, 10 (1999)
46. Proton Donor Promiscuity in an Aldo-keto Reductase, Khurana, S., Sanli, G., Powers, D.B., Anderson, S. and Blaber, M. FLACS 52, 49 (1999)
45. Construction and Characterization of a Synthetic Gene for 2,5-Diketo-D-Gluconate Reductase, Sanli, G., Blaber, S., Khurana, S. and Blaber, M. FLACS 52, 49 (1999)
44. The Role of Low Concentrations of Guanidine HCl in Reversible Denaturation of Human Acidic Fibroblast Growth Factor-1, Blaber, S.I., Culajay, J.F., Khurana, A. and Blaber, M. Biophysical Journal, 76, A107 (1999)
43. Deconvolution of Calorimetric Data for Protein Stability Studies, Grek, S., Davis, J. and Blaber, M. Proceedings of the 1^st Annual NASA Partners in Education and Research Conference (1998)
42. Crystal Structure of 2,5-diketo-D-Gluconic Acid Reductase A Complexed with NADPH at 2.1Resolution, Khurana, S., Powers, D.B., Anderson, S. and Blaber, M. Protein Science 7 (suppl. 1). 122 (1998)
41. Cysteine Residue Mutations in Human Acidic FGF and Effects upon Thermal Stability, Culajay, J.F., Blaber, S.I. and Blaber, M. FLACS 51, 44 (1998)
40. Structural Influence on Specificity and Catalytic Behavior in Serine Proteases, Badisa, R.B., Blaber, S.I. and Blaber, M. FLACS 51, 44 (1998)
39. Evaluation and Characterization of Mutations of Human Acidic Fibroblast Growth Factor to Enhance Thermal Stability and Biological Activity, Grek, S., Culajay, J.F. and Blaber, M. 21^st Annual Research Seminar, American Cancer Society (1998)
38. Effects of Low Concentrations of Guanidine Hydrochloride on the Stability and Reversible Denaturation of Human Acidic Fibroblast Growth Factor, Blaber, S. and Blaber, M. Proceedings of the 3^rd Annual Johns Hopkins Protein Folding Meeting (1998)
37. Structure Solved for Key Enzyme in Vitamin C Production, Blaber, M. Industrial Bioprocessing 19, 5 (1997)
36. Modulation of protein stability, Blaber, M. FLACS 50, 33 (1997)
35. The preliminary x-ray characterization and molecular replacement studies with 2,5-diketo-D-gluconate reductase crystals, Khurana, S., Powers, D. and Blaber, M. FLACS 50, 39 (1997)
34. An approach to accurate DSC analyses of irreversibly unfolding proteins, Adamek, D., Blaber, S., Culajay, J.F. and Blaber, M. FLACS 50, 59 (1997)
33. Contribution of the cysteine residues to the thermal and physiological stability of the human acidic fibroblast growth factor, Culajay, J.F., Blaber, S., Adamek, D., Khurana, S. and Blaber, M. FLACS 50, 59 (1997)
32. Mechanisms of Regulation of Human Acidic Fibroblast Growth Factor, Blaber, M., Adamek, D., Blaber, S., Culjay, J. and Khurana, S. 20^th Annual Research Seminar American Cancer Society, Florida Division (1997)
31. Avoiding the Aggravation of Aggregation: Denaturation Studies of Acidic Fibroblast Growth Factor, Adamek, D., Grek, S., Blaber, S. and Blaber, M. Proceedings of the 5^th Annual Suddath Symposium (1997)
30. The Use of Low Concentration Guanidine Hydrochloride to Achieve Reversible Thermal Denaturation of Acidic Fibroblast Growth Factor, Adamek, D., Blaber, S. and Blaber, M. Proceedings of the 2^nd Annual Johns Hopkins Protein Folding Meeting (1997)
29. Denaturation Studies of Human Acidic Fibroblast Growth Factor, Adamek, D., Popovic, A., Blaber, S. and Blaber, M. First International Conference on the Applications of Biocalorimetry, R-01 (1996)
28. Contribution of Free Cysteine Residues to the Stability of Human Acidic Fibroblast Growth Factor, Popovic, A., Adamek, D., Blaber, S. and Blaber, M. First International Conference on the Applications of Biocalorimetry, P-19 (1996)
27. X-ray Crystal Structure of Human Acidic Fibroblast Growth Factor, Blaber, M. Protein Science 5 (suppl. 1), 101 (1996)
26. Crystallographic Analysis of the Central Cavity of Interleukin-1b, Blaber, M., Yu, B., Bhyravbhatla, B. and Caspar, D.L.D. International Conference on Protein Folding and Design, National Institutes of Health (1996)
25. Structure and Function Studies of Mouse Glandular Kallikreins, Lang, E. and Blaber, M. Proceedings of the 4^th Annual Suddath Symposium (1996)
24. Stability Studies of Human Acidic Fibroblast Growth Factor. I. Effect of pH on the Enthalpy of Unfolding, Popovic, A., Adamek, D. and Blaber, M. Proceedings of the 4^th Annual Suddath Symposium (1996)
23. Stability Studies of Human Acidic Fibroblast Growth Factor. II. Effect of Denaturants on the Reversibility of Unfolding, Adamek, D., Popovic, A. and Blaber, M. Proceedings of the 4^th Annual Suddath Symposium (1996)
22. X-ray Crystal Structure of Human Acidic Fibroblast Growth Factor, Blaber, M. Proceedings of the 4^th Annual Suddath Symposium (1996)
21. Structure of Human Acidic Fibroblast Growth Factor, Blaber, M. 19^th Annual Research Seminar, American Cancer Society (1996)
20. pH Studies of Human Acidic Fibroblast Growth Factor, Adamek, D., Popovic, A. and Blaber, M. 19^th Annual Research Seminar, American Cancer Society (1996)
19. Protein Stability as a Regulatory Mechanism, Blaber, M. FLACS 48, 65 (1995)
18. Structure and Specificity Relationships in Serine Proteases, Lang, E. and Blaber, M. FLACS 48, 45 (1995)
17. Buried Cysteine Residues and Irreversible Protein Denaturation, Popovic, A. and Blaber, M. FLACS 48, 42 (1995)

Abstracts - Postdoctoral Fellow

16. Crystallographic Analysis of Mouse Pro-renin Converting Enzyme, Blaber, M. J. Cell. Biochem., Suppl. 18D, 151 (1994)
15. Data Collection from Crystals of Escherichia coli b-Galactosidase, Jacobson, R.H., Blaber, M., Dubose, R.F. and Matthews, B.W. Photon Factory Activity Report 11, 79 (1993)
14. Alpha Helix Propensity of Amino Acids - Technical Note Blaber, M., Zhang, X.-J. and Matthews, B.W. Science 262, 917-918 (1993)
13. Mutations Affecting Solvent Accessibility in a-Helices, Blaber, M., Baase, W.A. and Matthews, B.W. Protein Society, 6th Symposium Proceedings, 45 (1992)
12. Structural and Thermodynamic Consequences of Mutations which Introduce a Hydroxyl Group in T4 Lysozyme, Gassner, N., Blaber, M., Lindstrom, J.D. and Matthews, B.W. Protein Society, 6th Symposium Proceedings, 45 (1992)
11. Structural And Genetic Analysis Of The Interactions That Stabilize Proteins, Dao-pin, S., Nicholson, H., Zhang, X.-J., Baase, W.A., Blaber, M., Heinz, D. and Matthews, B.W. J. Cell. Biochem. 15G, 46 (1991)
10. Alanine-Serine Substitutions Within a-Helical Secondary Structure: Effects Upon Protein Stability, Blaber, M. and Matthews, B.W. J. Cell. Biochem. 15G, 205 (1991)

Abstracts - Graduate Student

9. Processing of Growth Factor Precursors, Bradshaw, R.A., Blaber, M. and Isackson, P.J. J. Cell. Biochem. 15G, 106 (1991)
8. The Kunitz Protease Inhibitory Domain of the Beta-amyloid Precursor Protein is Sufficient for its Protease Inhibitory Properties, Sinha, S., Dovey, H.F., Seubert, P., Ward, P.J., Blacher, R.W., Blaber, M., Bradshaw, R.A., Arici, M., Mobley, W.C. and Lieberburg, I. Neurobiology of Aging 11, 311 (1990)
7. Processing of Recombinant Nerve Growth Factor, Isackson, P.J., Blaber, M., Cavanaugh, K. and Bradshaw, R.A. Trophic Agents V, Society for Neuroscience Abstracts 15, 866 (1989)
6. Epidermal growth-factor binding-protein - A model serine protease for enzyme engineering, Blaber, M., Isackson, P.J. and Bradshaw, R.A., Journal of Cellular Biochemistry Suppl. 11C, 223 (1987)
5. Growth Factor Processing: Molecular Modelling of EGF and NGF Associated Kallikreins, Blaber, M., Blevins, R., Thomas, K.A., Isackson, P.J. and Bradshaw, R.A. Abst. 1st Symp. Protein Soc. (San Diego, CA) 42 (1987)

Abstracts - Research Technician

4. Natural and Recombinant High Molecular Weight Urokinase Contain a Kringle Specific Benzamidine Binding Site, Blaber, M. and Winkler, M.E. Thromb. Haemostasis 54, 103 (1985)
3. Molecular Characterization of Human Urokinase Produced in Bacteria as Compared to Urokinase Obtained from Human Urine, Steffens, G.J., Gunzler, W.A., Henninger, W., Hennies, H.H., Kim, S.M.A., Otting, F., Frankus, E., Flohe, L., Blaber, M. and Winkler, M.E. Haemostasis 14, 60 (1984)
2. Functional Characterization of Human Urokinase Produced in Bacteria as Compared to Urokinase Obtained from Human Urine, Gunzler, W.A., Henninger, W., Hennies, H.H., Otting, G., Schneider, J., Frederichs, E., Giertz, H., Flohe, L., Blaber, M. and Winkler, M.E. Haemostasis 14, 60 (1984)
1. The Comparison of E. coli Recombinant Urokinase with Natural Urokinase, Winkler, M.E., Blaber, M. and Vehar, G.A. Thromb. Haemostasis 50, 386 (1983)

(c) 2009 Michael Blaber, Ph.D.